What is the non-invasive prenatal test in pregnancy or TPNI

Amniocentesis is a test that is performed between the 16th and 22nd week of pregnancy to find out if there are any chromosomal abnormalities in the baby, such as Down syndrome.

The problem with amniocentesis is that it is a test that involves risks to the baby, with a 0.3 to 1% probability of having an abortion, which means that many women do not have it out of fear.

The Non-invasive prenatal test in pregnancy (TPNI)It can be an alternative to know the genetic alterations of the baby, with a simple blood test of the mother.

This test began to be practiced in 2013 and is a break for those mothers who are afraid of having amniocentesis, since with a simple blood test we can know, with great chances of success, if our baby has a genetic alteration or not.

Although, like all tests, it has some advantages and some disadvantages compared to amniocentesis.

Advantages of the non-invasive prenatal test in pregnancy

- There are no risks to the baby.

- It is capable of detecting the main chromosomal alterations such as Down syndrome, Patau and Edward.

- It is 99% reliable in detecting trisomies.

- It can be done from the week 10 of pregnancy, while amniocentesis, is done from week 16.

- We have the result between 1 and 2 weeks.

- It is perfect for when we have a twin pregnancy, even after egg donation.

- Detects cases of missing twin and triploidy.

Drawbacks of the non-invasive prenatal test in pregnancy

- It is not recommended if you have had a blood transfer in less than 6 months, or a bone marrow transplant.

- If a high risk was found in the screening test, it does not serve to confirm.

- It is a test of suspicion and not of certainty.

- There is a 5% probability of a false positive, and it is necessary to confirm it with an invasive test such as amniocentesis or chorionic biopsy.

- There is a 2.5% probability of get no results, especially in cases of obesity.

- In the case of twin pregnancy there are times when they cannot tell us the sex of babies.

- It has a high cost, between 400 and 900 euros.

- It does not replace the fetal ultrasound at week 20, since it does not detect malformations.

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